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KMID : 0360219900310060753
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Journal of the Korean Ophthalmological Society
1990 Volume.31 No. 6 p.753 ~ p.760
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Experimental Intraocular Fibrovascular Proliferation Through Sclerotomy Wound
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Lim Jin-Ock
Park Ki-Ho
Lee Jae-Heung
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Abstract
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In the process of closing a sclera] wound caused by various conditions, incarcera-tion of the conjunctiva, Tenon’s capsule or vitreous in the wound can occur unex-pectedly. We created such conditions experimentally to determine their intraocular complications. The experimental materials were 12 albino rabhits(24 eyes) and the rabbits were divided into two groups( I & II). Group I rabbits(12 eyes) received no vitrectomy and group II rabbits(12 eyes) received a vitrectomy. After the conjunctiva and Tenon’s capsule flap was made, the tissue flap was inserted into the vitreous cavity through the sclerotomy site. Fundus examination with an indirect ophthalmoscope and enucleation for histology were performed at 3 days, 1 week, 3 weeks, 6 weeks, 3 months and 6 months after the experiment.
The results were as follows:
1. Intraocular fibrovascular proliferation developed in all experimental rabbit eyes.
2. The More vitreous hemorrhage developed, the greater was the fibrovascular proliferation and the degree of fibrovascular proliferation was more marked in group II than group I.
3. The fibrovascular proliferation developed to a band in 3 weeks, then regres-sed gradually.
4. The fibrovascular band was composed of fibroblasts, stromal matrix and few vessels.
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KEYWORD
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fibroblasts, intraocular fibrovascular proliferation, sclerotomy, vitreous hemor-rhage
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